This report presents a transgenic mouse, which differs from previously reported and commercially available mice, in that enhanced yellow fluorescent protein expression EYFP is driven by the human thy1 promoter hThy1. Motor and sensory peripheral nerves in these mice appear a bright yellow-green under fluorescent microscopy. This study tracks nerve regeneration in live animals using a serial imaging system. It also introduces a novel model for examining the clinically relevant nerve-injury paradigms of tibial nerve transection repaired with primary neurorrhaphy or graft, and end-to-side neurorrhaphy.
Register for a free account
Live-animal serial nerve imaging is compared with wet-mount fluorescent microscopy and histomorphometry in the same nerve specimens. The use of transgenic mice that strongly express EYFP in their peripheral neurons, coupled with serial nerve imaging, provide an important methodology for studying the heterogeneous nature of axonal elongation following peripheral-nerve injuries. This is why when injury occurs, we first feel sharp, acute pain that then slowly diffuses into a duller ache.
- The Myth of the Strong Leader: Political Leadership in the Modern Age.
- Inside the Business of Graphic Design: 60 Leaders Share Their Secrets of Success?
- Caribbeana: An Anthology of English Literature of the West Indies, 1657-1777;
- Change Password.
- Analytical and Computational Methods of Advanced Engineering Mathematics (Texts in Applied Mathematics).
- Management for the XXI Century: Education and Development?
Once the incoming signal is transmitted to the CNS at the spinal cord, primary afferent neurons synapse on second order neurons. From there, information travels on to the thalamus via multiple neurons that have the capacity to change their response patterns when activity of nociceptive fibers is sustained as occurs in the setting of a tissue or nerve injury and perhaps in the setting of psychological trauma.
This is known as modulation of the incoming nociceptive stimulus.
Paradigms of Neural Injury, Vol 30. Methods in Neurosciences
During this step of the process, stimuli can be amplified, suppressed, or even transformed from one type to another eg, a light touch can be modulated in such a way that it will be perceived as a burning sensation. Also, it is this step that is affected by many medications, by intrathecal drug infusions, and by spinal neurostimulators.
In perception , the thalamus then directs the pain sensation to multiple brain centers. At this step, the stimulus is finally consciously perceived as pain by the individual.
Changing the Therapeutic Paradigm of TBI | West Laboratory
Cortical pain circuits can be activated without physical input ie, no tissue damage, noxious stimuli, or nerve injury. This becomes important in understanding pain syndromes, such as fibromyalgia. True or False.
To treat carpal tunnel syndrome CTS due to repetitive wrist motion, clinicians should consider continuous use of a wrist splint for 2 to 4 weeks. Skip to main content. Applied Evidence.
A new paradigm for pain?